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doi: 10.1126/scitranslmed.aah4477 Summary Keywords metabolic syndrome, atherosclerotic cardiovascular disease, hypertension, endothelial dysfunction, platelet hyperactivity Citation Das D, Shruthi NR, Banerjee A, Jothimani G, Duttaroy AK and Pathak S (2023) Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies

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Concurrently, insulin resistance and resultant hyperinsulinemia impair chondrocyte homeostasis via the PI3K/Akt pathway, leading to suppressed FOXO1 transcription factor activity